As the chief of medical toxicology at UMass Chan Medical School, I have studied fentanyl and its analogs for years. As fentanyl has become ubiquitous across the U.S., it has transformed the illicit drug market and raised the risk of overdose. Due to high levels of stress, first responders and health care workers are at risk for substance use disorders.

The Share Of US Drug Overdose Deaths Caused By Fake Prescription Pills Is Growing
Deaths from fentanyl — the synthetic, often deadly opioid frequently present in illicit street drugs — have contributed to the United States’ soaring opioid overdose deaths in the last decade. It is commonly mixed with drugs like heroin, cocaine, and methamphetamine and made into pills that are made to resemble other prescription opioids. Drugs mixed with fentanyl are extremely dangerous, and many people may be unaware that their drugs contain it. In addition to receiving treatment for a substance use disorder, people who use illegal drugs can help prevent overdoses by using fentanyl test strips. These are low-cost paper strips that can detect fentanyl in all kinds and forms of substances. Other strategies to prevent overdose deaths include lowering the entry barrier to addiction treatment, fentanyl test strips, supervised consumption sites and even prescription diamorphine (heroin).
As a result, it is much more profitable to cut a kilogram of fentanyl compared to a kilogram of heroin. This medicine may cause sleep-related breathing problems (eg, sleep apnea, sleep-related hypoxemia). Your doctor may decrease your dose if you have sleep apnea (stop breathing for short periods during sleep) while using this medicine. It is very important that your doctor check your or your child’s progress while using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
And there are Good Samaritan laws to protect people seeking and giving help during an opioid overdose. According to GoodRx, there are also three states that provide free Narcan in general. And then cities like Philadelphia and Chicago offer it for free in public libraries. But this new FDA over-the-counter approval would really make it more available everywhere. In a long anticipated decision, the Food and Drug Administration approved an over-the-counter version of naloxone spray, a generic form of the opioid overdose treatment called Narcan. Narcan is the brand name for Naloxone; a life-saving opioid antagonist medication that quickly reverses an opioid overdose.
- Illegally manufactured fentanyl is found in heroin, cocaine, methamphetamine and in counterfeit pills.
- Despite the number and diversity of its analogs, fentanyl itself continues to dominate the illicit opioid supply.
- People can test positive for fentanyl for 3 to 5 days after last use.
- Because fentanyl is so potent and commonly found in the drug supply, it is easy for people to accidentally overdose on fentanyl.
- If you suspect someone is having a fentanyl or other opioid overdose, you can administer Narcan to try and revive them.
Why Is It So Dangerous?
This is the captive audience Hernandez takes advantage of, walking in front of the assembled people, holding brightly colored public health brochures above her head. In Los Angeles County, health officials have launched a unique push to get Narcan into the hands of an overlooked demographic when it comes to the overdose epidemic — Latino immigrants. Many private health insurers — and public programs like Medicaid and Medicare — cover the cost of these prescription sales. Other signs of an overdose may include a pale or clammy face, and discoloration of the lips or fingernails, according to the CDC.
Health Care Providers
The effects of fentanyl (and all opioids) can be blocked and reversed with the use of Narcan. Anyone can purchase Narcan over the counter, and there are places that give it away for free (see below). Outside of medical settings, fentanyl appears as a white powder. It is also used to cut drugs, meaning it’s mixed with other substances to make the quantity of the secondary substance stretch. As Vox’s German Lopez previously explained, fentanyl has been around since the 1960s, but its illicit use has spiked in recent years. It is relatively easy to produce and is much more potent than heroin.
The US government, in an effort to reduce drug abuse, introduced a law to prevent OTC Opioids from being sold. So, the opiates that filled pharmacy store shelves went away. While you may think all drugs should be legal, many would disagree. History has shown that society may be better off with dangerous drugs being illegal or, at least, a lot harder for people to obtain. In order to find them, you would have to dial your time travel device back to the turn of the 20th century.
NIH-funded Intervention Did Not Impact Opioid-related Overdose Death Rates Over Evaluation Period
Dispose of partially used lozenges according to the manufacturer’s directions immediately after you remove them from your mouth. If fentanyl is used by a child or an adult who has not been prescribed the medication, try to remove the medication from the person’s mouth and get emergency medical help. Because the drug is less expensive than other opioids, people making it illegally commonly mix it into drugs such as heroin, cocaine, or methamphetamines. If you buy drugs illegally, there is a chance fentanyl can be in them. Fentanyl is a human-made opioid used to treat severe pain. The drug interacts with receptors in your brain to create feelings of pain relief, relaxation, contentment, and pleasure.

Can You Buy Fentanyl Over The Counter
Unfortunately, fentanyl’s high potency also means that even just a small amount can prove deadly. If the end user isn’t aware that the drug they bought has been adulterated, this could easily lead to an overdose. In summary, fentanyl is not available for over-the-counter purchase and is closely regulated due to its potential for misuse and serious health risks. It’s vital to consult healthcare professionals regarding pain management options. Fentanyl overdose often comes on much faster and stronger than a typical opioid overdose. In some cases, a person’s chest may become very stiff (called “chest wall rigidity” or “wooden chest”).
An opioid drug antagonist such as naloxone can help to correct OIRD symptoms. Thus, the therapeutic approach should continue until a normal respiratory rate coincides with appropriate oxygen saturation levels. It’s one of the most common drugs involved in overdose deaths.
Can A Person Overdose On Fentanyl?

People taking a daily prescribed dose will become dependent on the drug and will have withdrawal symptoms if they stop it. This is not an addiction but instead a physiological response. When it is intentionally misused, fentanyl often shows up as a powder, spiked on blotter paper or is mixed with or substituted for heroin and other street drugs. If the patient has used a monoamine oxidase inhibitor in the previous 14 days, fentanyl is contraindicated. There are two types of fentanyl – pharmaceutical fentanyl and illegally made fentanyl.
Breathing air in a room with fentanyl can’t make you sick. Medical experts said fentanyl isn’t volatile, meaning it doesn’t easily become a vapor, which means you’re not going to become sick from breathing near it. Experts said fentanyl doesn’t just float up into the air and unintentionally expose people nearby. Fentanyl use can result in death even with one dose, especially if a person accidentally takes it incorrectly.

All narcotic drugs — including fentanyl, heroin, and legal opioids like morphine — cause the pupils to constrict. Having “pinpoint pupils” is one symptom of overdose, especially if the pupils do not dilate in response to changes in light. Fentanyl can be made to look like cocaine, heroin, or prescription opioids in pill or powder form. It also comes as a liquid, as in nasal sprays or eye drops, which can be dropped onto paper like LSD. Illicitly manufactured fentanyl is internationally synthesized in China, Mexico and India, then exported to the United States as powder or pressed pills.

What Is Naloxone?
Narcan is an opioid reversal medication, which works by binding to the opioid receptors to the brain, effectively “kicking off” the opioids from the receptors and replacing them for a limited amount of time. This can quickly reverse an overdose and restore breathing. On Wednesday, the FDA announced that it has approved the sale of naloxone nasal spray, also known as Narcan, for sale over-the-counter to treat opioid overdose. Previously, the medication had only been available by prescription.
This can make it harder for the victim to breathe and for a responder to do chest compressions. Fentanyl test strips can identify the presence of fentanyl in unregulated drugs. They can be used to test injectable drugs, powders, and pills. If you choose to use fentanyl, there are some practices that can help you minimize the risk of an overdose. Here are a few recommendations so you can be in control of your experience.
A fentanyl overdose can occur after the drug is injected, swallowed, snorted, or smoked. Symptoms of a fentanyl overdose, including slow or absent breathing, generally occur within minutes of the overdose. Death can follow quickly if the overdosed person isn’t treated.